Reactions
Reactants Reagents Products Help
CCC(=O)C Magnify [Li+].[N-](C(C)C)C(C)C
THF, -78o C
[Li+].CCC(=C)[O-] Magnify

Note: Direct enolate formation with a very strong and bulky base like LDA. Note the regioselective preference for the less substituted (and thus less hindered) 'kinetic enolate.'


CCC(=O)C(C)C Magnify [Li+].[N-](C(C)C)C(C)C
THF, -78o C
[Li+].C/C=C(/C(C)C)\[O-] Magnify

Note: Direct enolate formation with LDA. Again note the regioselective preference for the kinetic enolate based on the bulky base and low reaction temperature.


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